Epithelial cell proliferation involved in salivary gland morphogenesis

pathway activity — cross-omics
GO:0060664Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Epithelial cell proliferation involved in salivary gland morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DHX30, MDN1_T4898, and COL5A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADDHX30 →-0.146-0.041.002<.00134
GBMMDN1_T4898 →-0.343-0.100.001<.00134
OVCOL5A1 →-0.442-0.064.006.00634
GBMCNN3 →-0.283-0.085<.001.00234
BRCASLC7A2_S646 →+2.269+0.137<.001.00133
BRCASPATA18_S507 →+0.677+0.102.002<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration