Epithelial cell proliferation involved in salivary gland morphogenesis

pathway activity — cross-omics
GO:0060664Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Epithelial cell proliferation involved in salivary gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK2AP2, CCDC13-AS1, and EI24P3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCDK2AP2 →-0.599-0.153.007<.00132
GBMCCDC13-AS1 →+0.931+0.114.003.00332
GBMEI24P3 →+0.433+0.114.005.00332
UCECDLG1-AS1 →+0.424+0.428.004.00832
GBMNKAIN4 →+3.578+0.114<.001.00331
GBMST8SIA5 →+1.563+0.114.003.00331
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration