Mammary gland epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Mammary gland epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM114A2, PLCB2, and HK3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland epithelial cell differentiation activity versus FAM114A2 in OV (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM114A2 →	-0.247	-0.047	.005	.003	3	6
LSCC	PLCB2 →	-0.419	-0.089	<.001	<.001	3	6
LSCC	HK3 →	-0.378	-0.064	<.001	<.001	3	6
OV	RUNX1_S21 →	-0.632	-0.058	.001	<.001	3	5
GBM	SERPINB10 →	-0.819	-0.074	.001	<.001	3	5
OV	PPP1R18_S368 →	-0.588	-0.042	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060644 vs FAM114A2 — OV

Explore this scatter interactively →