Mammary gland epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Mammary gland epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC17A3, MRPS6P2, and SNORA54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland epithelial cell differentiation activity versus SLC17A3 in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC17A3 →	+0.063	+0.595	.002	.003	3	3
BRCA	MRPS6P2 →	+0.169	+0.512	<.001	.002	3	3
OV	SNORA54 →	-0.680	-0.645	<.001	.005	3	3
UCEC	PLN →	+0.941	+0.682	.001	<.001	3	3
HNSC	RPL12P4 →	+1.216	+0.665	<.001	.001	3	3
LUAD	LINC01714 →	+0.677	+0.489	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060644 vs SLC17A3 — BRCA

Explore this scatter interactively →