Mammary gland epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Mammary gland epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSMAF, CNIH1, and SERP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NSMAF grouped by Mammary gland epithelial cell differentiation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NSMAF →	+0.865	+1.185	.002	.005	3	4
BONE	CNIH1 →	+0.951	+1.579	.009	<.001	3	4
SKIN	SERP1 →	+0.939	+1.198	.001	<.001	3	4
SKIN	CHUK →	-0.505	-0.976	.001	.001	3	4
KIDNEY	MTARC1 →	+1.674	+0.856	.003	.005	3	3
BONE	GALNT4 →	-2.147	-1.051	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NSMAF by Mammary gland epithelial cell differentiation activity — OESOPHAGUS

Explore this box plot interactively →