Mammary gland epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Mammary gland epithelial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAT1, MARCHF10, and PRSS21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAT1 grouped by Mammary gland epithelial cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRAT1 →	+0.133	+0.109	.004	.002	3	4
BLOOD_Myeloma	MARCHF10 →	-0.395	-0.262	.005	.002	3	4
SOFT_TISSUE	PRSS21 →	-0.364	-0.200	.003	.007	3	4
BREAST	KDELR1 →	+0.190	+0.202	<.001	.001	3	4
BLOOD_Myeloma	FASLG →	+0.227	+0.201	.001	<.001	3	4
BLOOD_Myeloma	MSX1 →	+0.225	+0.183	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAT1 by Mammary gland epithelial cell differentiation activity — SKIN

Explore this box plot interactively →