Regulation of microtubule-based movement

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule-based movement pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAF3IP1, WDR35, and WDR54, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule-based movement activity versus TRAF3IP1 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRAF3IP1 →	+0.395	+0.040	.007	.006	3	7
UCEC	WDR35 →	+0.401	+0.085	<.001	<.001	3	7
UCEC	WDR54 →	+0.545	+0.093	<.001	<.001	3	7
UCEC	CETN2 →	+0.403	+0.082	<.001	<.001	3	7
UCEC	IFT140 →	+0.397	+0.087	<.001	<.001	3	7
GBM	IFT74 →	+0.428	+0.066	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060632 vs TRAF3IP1 — OV

Explore this scatter interactively →