Regulation of microtubule-based movement

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule-based movement pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2, TSPAN7, and RNA5SP118, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule-based movement activity versus MAP2 in LSCC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP2 →	+1.887	+0.759	<.001	<.001	3	6
GBM	TSPAN7 →	+1.100	+0.313	<.001	<.001	3	5
LSCC	RNA5SP118 →	+1.583	+0.709	<.001	<.001	3	5
GBM	PTPN5 →	+0.946	+0.285	<.001	<.001	3	5
LSCC	ADAMTS8 →	+0.772	+0.882	<.001	<.001	3	5
GBM	CXXC4 →	+1.041	+0.332	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060632 vs MAP2 — LSCC

Explore this scatter interactively →