Regulation of ER to Golgi vesicle-mediated transport

Across TCGA patient cohorts, RNA activity of the Regulation of ER to Golgi vesicle-mediated transport pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMO, POLD2, and TBC1D4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ER to Golgi vesicle-mediated transport activity versus SMO in HNSC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SMO →	-0.663	-0.183	.004	.002	3	6
LSCC	POLD2 →	-0.738	-0.522	<.001	<.001	3	5
GBM	TBC1D4 →	-0.404	-0.181	.002	.004	3	4
GBM	GASK1B →	-0.843	-0.149	<.001	.004	3	4
PDAC	MFAP5 →	-0.847	-0.172	.005	<.001	3	4
GBM	BNC2-AS1 →	-0.643	-0.145	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060628 vs SMO — HNSC

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