Mammary gland duct morphogenesis

Across TCGA patient cohorts, RNA activity of the Mammary gland duct morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EXOC2, SHROOM1_S224, and LYPLAL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland duct morphogenesis activity versus EXOC2 in COAD (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EXOC2 →	+0.142	+0.037	.003	.001	3	5
BRCA	SHROOM1_S224 →	+0.800	+0.037	<.001	<.001	3	5
BRCA	LYPLAL1 →	+0.309	+0.054	.002	<.001	3	5
OV	RPLP2 →	-0.324	-0.063	<.001	<.001	3	4
LUAD	SFXN3 →	+0.405	+0.049	<.001	.004	2	5
UCEC	SNIP1_S153 →	-0.680	-0.117	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060603 vs EXOC2 — COAD

Explore this scatter interactively →