Mammary gland duct morphogenesis

Across TCGA patient cohorts, RNA activity of the Mammary gland duct morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCSK6, CLEC1A, and FABP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland duct morphogenesis activity versus PCSK6 in BRCA (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCSK6 →	+0.903	+0.884	<.001	<.001	3	4
PDAC	CLEC1A →	-0.309	-0.519	.001	.003	3	4
PDAC	FABP4 →	-0.964	-0.773	<.001	<.001	3	4
GBM	KCNA2 →	-1.025	-0.779	.001	<.001	3	4
BRCA	SYBU →	+1.044	+0.858	.001	<.001	3	4
GBM	PPP2R2B →	-0.483	-0.566	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060603 vs PCSK6 — BRCA

Explore this scatter interactively →