Mammary gland duct morphogenesis

Across TCGA cell cohorts, RNA activity of the Mammary gland duct morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR2F, CCDC134, and DDX17, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland duct morphogenesis activity versus POLR2F in OVARY (Pearson r = -0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	POLR2F →	-1.360	-0.608	.002	.005	1	1
OVARY	CCDC134 →	-0.815	-0.608	<.001	.005	1	1
OVARY	DDX17 →	-0.524	-0.608	.009	.005	1	1
OVARY	POLDIP3 →	-0.540	-0.608	<.001	.005	1	1
OVARY	HMGXB4 →	-0.935	-0.608	.002	.005	1	1
OVARY	SGSM3 →	-1.040	-0.608	.008	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060603 vs POLR2F — OVARY

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