Branch elongation of an epithelium

Across TCGA cell cohorts, RNA activity of the Branch elongation of an epithelium pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM26, RGP1, and EIF3J, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM26 grouped by Branch elongation of an epithelium-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RBM26 →	-1.518	-1.704	<.001	<.001	3	5
BLOOD_Myeloma	RGP1 →	+0.490	+1.288	.004	.005	3	4
CNS	EIF3J →	-0.420	-1.032	.006	.002	3	4
UPPER_AERODIGESTIVE_TRACT	RRP12 →	-0.880	-1.351	.009	.008	3	4
LIVER	GNAS →	-0.448	-1.302	.008	.002	3	4
UPPER_AERODIGESTIVE_TRACT	SRSF4 →	-1.024	-1.614	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM26 by Branch elongation of an epithelium activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →