Dichotomous subdivision of an epithelial terminal unit

Across TCGA cell cohorts, RNA activity of the Dichotomous subdivision of an epithelial terminal unit pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COP1, GCA, and KCNIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COP1 grouped by Dichotomous subdivision of an epithelial terminal unit-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	COP1 →	-0.559	-1.647	.001	<.001	2	5
OVARY	GCA →	+1.237	+1.279	<.001	<.001	3	4
KIDNEY	KCNIP2 →	+0.569	+1.022	<.001	.006	3	3
KIDNEY	CLIC1 →	-0.736	-1.451	.005	.005	3	3
SKIN	RABGGTA →	-0.495	-1.185	.002	.002	3	3
SKIN	FKRP →	-0.781	-1.639	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COP1 by Dichotomous subdivision of an epithelial terminal unit activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →