Chondroblast differentiation

Across TCGA cell cohorts, RNA activity of the Chondroblast differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCA4, ARHGEF11, and NSUN7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMARCA4 grouped by Chondroblast differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMARCA4 →	-0.477	-1.009	<.001	.002	3	5
OVARY	ARHGEF11 →	+0.148	+1.096	<.001	<.001	3	5
SOFT_TISSUE	NSUN7 →	+0.402	+1.630	<.001	<.001	3	5
URINARY_TRACT	KCNJ12 →	-0.166	-1.804	.004	<.001	3	5
OVARY	TRAPPC3 →	-0.240	-1.371	.008	<.001	3	5
OVARY	EPB41L4B →	-0.153	-1.480	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMARCA4 by Chondroblast differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →