Multicellular organismal-level iron ion homeostasis

Across TCGA patient cohorts, RNA activity of the Multicellular organismal-level iron ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMOD1_S85, FERMT2, and BGN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level iron ion homeostasis activity versus LMOD1_S85 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1_S85 →	+1.097	+0.097	.001	<.001	3	7
HNSC	FERMT2 →	+0.443	+0.057	<.001	.003	3	7
BRCA	BGN →	+0.700	+0.057	<.001	<.001	3	6
UCEC	GSN →	+0.372	+0.068	.002	.001	3	6
UCEC	HNMT →	+0.421	+0.072	.001	.001	3	6
GBM	SEPTIN4 →	+0.719	+0.049	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060586 vs LMOD1_S85 — UCEC

Explore this scatter interactively →