Multicellular organismal-level iron ion homeostasis

Across TCGA patient cohorts, RNA activity of the Multicellular organismal-level iron ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGI2-AS3, AOC3, and ARHGAP31, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level iron ion homeostasis activity versus MAGI2-AS3 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAGI2-AS3 →	+0.794	+0.376	.003	.005	3	6
OV	AOC3 →	+1.352	+0.427	.002	.004	3	6
PDAC	ARHGAP31 →	+0.288	+0.198	.002	.002	3	6
OV	EFEMP1 →	+2.082	+0.387	<.001	.004	3	5
BRCA	DIPK1A →	+0.580	+0.384	.003	.002	3	5
BRCA	APOD →	+1.807	+0.259	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060586 vs MAGI2-AS3 — OV

Explore this scatter interactively →