Multicellular organismal-level iron ion homeostasis

Across TCGA patient cohorts, RNA activity of the Multicellular organismal-level iron ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYBRD1_S260, CYBRD1_T285, and TNS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level iron ion homeostasis activity versus CYBRD1_S260 in PDAC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CYBRD1_S260 →	+1.519	+0.249	<.001	<.001	3	8
COAD	CYBRD1_T285 →	+0.636	+0.199	<.001	<.001	3	5
UCEC	TNS2 →	+0.363	+0.241	<.001	<.001	3	5
HNSC	SNX2 →	+0.211	+0.168	<.001	<.001	3	4
UCEC	MRC2 →	+0.611	+0.252	<.001	<.001	3	4
OV	TMEM119 →	+0.834	+0.352	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060586 vs CYBRD1_S260 — PDAC

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