Multicellular organismal-level iron ion homeostasis

Across TCGA cell cohorts, RNA activity of the Multicellular organismal-level iron ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP23, NDUFS2, and COL6A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multicellular organismal-level iron ion homeostasis activity versus ARHGAP23 in BONE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARHGAP23 →	+1.528	+0.295	.001	.003	3	6
STOMACH	NDUFS2 →	-0.718	-0.292	.006	.001	2	6
URINARY_TRACT	COL6A1 →	+4.399	+0.421	.002	<.001	3	5
STOMACH	CORT →	-0.445	-0.323	.002	<.001	3	5
OESOPHAGUS	RPL9 →	-1.184	-0.246	.003	.007	3	4
LARGE_INTESTINE	POP5 →	-0.514	-0.210	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060586 vs ARHGAP23 — BONE

Explore this scatter interactively →