Cell fate commitment involved in pattern specification

Across TCGA cell cohorts, RNA activity of the Cell fate commitment involved in pattern specification pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AUTS2, NDUFA10, and PSTPIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AUTS2 grouped by Cell fate commitment involved in pattern specification-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AUTS2 →	-0.184	-1.266	.002	.002	3	5
LUNG_SCLC	NDUFA10 →	+0.280	+1.427	.001	.007	3	4
LUNG_SCLC	PSTPIP2 →	+0.123	+1.573	<.001	.001	3	4
LUNG_SCLC	CHD7 →	+0.376	+1.430	.003	.001	3	4
BLOOD_Myeloma	IL17RB →	+0.256	+0.129	.005	.009	3	3
BLOOD_Lymphoma	TTC33 →	+0.300	+0.179	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AUTS2 by Cell fate commitment involved in pattern specification activity — LUNG_SCLC

Explore this box plot interactively →