Intestinal epithelial cell development

Across TCGA patient cohorts, RNA activity of the Intestinal epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, MTF2, and KIF5A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial cell development activity versus SDC4 in UCEC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SDC4 →	+0.610	+0.272	.002	.007	3	3
GBM	MTF2 →	-0.322	-0.120	.003	.002	3	3
GBM	KIF5A →	-0.968	-0.125	.002	.001	3	3
GBM	LRP8 →	-0.574	-0.137	.001	<.001	3	3
GBM	ARHGEF7-AS1 →	-0.690	-0.143	.001	<.001	3	3
BRCA	CCDC32 →	+0.252	+0.466	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060576 vs SDC4 — UCEC

Explore this scatter interactively →