Intestinal epithelial cell development

Across TCGA cell cohorts, RNA activity of the Intestinal epithelial cell development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCCPDH, NOB1, and SLC12A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SCCPDH grouped by Intestinal epithelial cell development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SCCPDH →	+0.702	+1.115	.002	.006	3	4
BONE	NOB1 →	-0.774	-1.592	.002	.001	3	4
SOFT_TISSUE	SLC12A2 →	+0.852	+1.468	.004	.002	2	4
LARGE_INTESTINE	C4BPB →	+2.783	+0.802	<.001	.003	3	3
LARGE_INTESTINE	ZRSR2 →	-0.575	-0.833	<.001	.003	3	3
BLOOD_Lymphoma	ACADM →	-0.942	-2.029	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SCCPDH by Intestinal epithelial cell development activity — SOFT_TISSUE

Explore this box plot interactively →