Intestinal epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Intestinal epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDC4, MED13L_S923, and DSP_S176, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial cell differentiation activity versus SDC4 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SDC4 →	+0.538	+0.050	<.001	<.001	3	5
BRCA	MED13L_S923 →	-0.546	-0.038	.001	.004	3	5
PDAC	DSP_S176 →	+0.468	+0.042	.005	<.001	3	5
LSCC	RSF1_S1359 →	-0.438	-0.053	<.001	.001	3	4
LUAD	ATF7IP_S113 →	-0.557	-0.065	<.001	<.001	3	4
LSCC	BPI →	+1.147	+0.065	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060575 vs SDC4 — LSCC

Explore this scatter interactively →