Intestinal epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Intestinal epithelial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, PRKCZ, and RRAD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TYMS grouped by Intestinal epithelial cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TYMS →	-0.734	-0.826	<.001	<.001	3	6
BREAST	PRKCZ →	-0.170	-0.579	.001	.005	3	4
OVARY	RRAD →	-0.178	-0.837	<.001	.001	3	4
BONE	WDR92 →	-0.274	-1.255	<.001	.001	3	4
OVARY	SOX9 →	-0.205	-0.848	<.001	.003	3	4
OVARY	FZD5 →	-0.245	-0.798	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TYMS by Intestinal epithelial cell differentiation activity — BREAST

Explore this box plot interactively →