Intestinal epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Intestinal epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRC, TNFAIP3, and TRPC4AP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial cell differentiation activity versus SRC in STOMACH (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SRC →	+1.975	+0.113	.006	.001	3	8
BLOOD_Leukemia	TNFAIP3 →	+1.217	+0.731	<.001	<.001	3	7
LUNG_NSCLC_LUAD	TRPC4AP →	+0.388	+0.076	<.001	.002	3	6
BLOOD_Lymphoma	MAML2 →	+1.214	+0.727	<.001	<.001	3	6
BLOOD_Lymphoma	ARHGEF12 →	+0.848	+0.855	.006	<.001	3	6
BLOOD_Leukemia	SDHAF3 →	-1.223	-0.911	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060575 vs SRC — STOMACH

Explore this scatter interactively →