Intestinal epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Intestinal epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1B, FBXO5, and RAD18, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial cell differentiation activity versus TUBA1B in URINARY_TRACT (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TUBA1B →	+2.350	+1.915	.005	.007	2	6
LARGE_INTESTINE	FBXO5 →	+0.738	+1.092	.004	.008	3	5
LARGE_INTESTINE	RAD18 →	+0.468	+0.854	.009	.001	3	5
PANCREAS	CDCA8 →	+0.694	+0.898	.009	.006	3	4
PANCREAS	INCENP →	+0.879	+0.879	<.001	.008	3	4
URINARY_TRACT	NCAPD3 →	+1.930	+1.851	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060575 vs TUBA1B — URINARY_TRACT

Explore this scatter interactively →