Intestinal epithelial cell maturation

pathway activity — cross-omics
GO:0060574Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Intestinal epithelial cell maturation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF22, KRT23_S65, and ACOT7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVKIF22 →+0.425+0.065.003.00934
OVKRT23_S65 →-1.340-0.064.001.00834
UCECACOT7 →+0.360+0.064.004.00834
PDACCARMIL1 →+0.177+0.051.005.00834
BRCASMC2 →+0.412+0.051.006.00134
BRCAAHCTF1_S1541 →+0.543+0.046.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration