Morphogenesis of an epithelial fold

Across TCGA patient cohorts, RNA activity of the Morphogenesis of an epithelial fold pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KRT19, TANC1, and CALD1_S202, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of an epithelial fold activity versus KRT19 in HNSC (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRT19 →	+1.440	+0.098	<.001	.002	3	6
HNSC	TANC1 →	+0.349	+0.123	<.001	<.001	3	5
HNSC	CALD1_S202 →	-0.807	-0.090	.003	.008	3	5
HNSC	ANK2 →	-0.529	-0.102	.001	.002	3	5
LSCC	NFATC2_S236 →	-0.626	-0.086	.001	<.001	3	5
OV	PSAT1 →	+0.903	+0.039	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060571 vs KRT19 — HNSC

Explore this scatter interactively →