Morphogenesis of an epithelial fold

Across TCGA patient cohorts, RNA activity of the Morphogenesis of an epithelial fold pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP3, ITGB5, and CEP112, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Morphogenesis of an epithelial fold activity versus IGFBP3 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IGFBP3 →	+1.645	+0.365	<.001	<.001	3	6
PDAC	ITGB5 →	+0.403	+0.216	<.001	<.001	3	6
BRCA	CEP112 →	+0.587	+0.466	<.001	.004	3	5
BRCA	HTRA1 →	+1.181	+0.485	<.001	.005	3	5
BRCA	SUGCT →	+0.729	+0.410	<.001	<.001	3	5
UCEC	LAMC1 →	+0.666	+0.360	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060571 vs IGFBP3 — GBM

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