Neuroepithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Neuroepithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are F10, PROS1, and BCHE, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroepithelial cell differentiation activity versus F10 in BRCA (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	F10 →	+0.586	+0.026	.001	.007	3	7
BRCA	PROS1 →	+0.592	+0.036	<.001	<.001	3	7
BRCA	BCHE →	+0.629	+0.038	<.001	<.001	3	7
PDAC	C1S →	+0.288	+0.040	.005	.001	3	6
PDAC	C4A →	+0.503	+0.041	.003	.002	2	7
CCRCC	C6 →	+0.458	+0.040	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060563 vs F10 — BRCA

Explore this scatter interactively →