Neuroepithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Neuroepithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM117B, DCAF12, and ACVR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM117B grouped by Neuroepithelial cell differentiation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FAM117B →	-1.329	-0.251	.001	.005	3	4
LUNG_NSCLC_LUSC	DCAF12 →	-1.265	-0.256	.009	.005	3	4
LUNG_SCLC	ACVR1 →	+0.782	+0.336	.001	.001	3	4
OESOPHAGUS	KIAA1143 →	-0.600	-0.177	.002	.001	3	3
LUNG_NSCLC_LUSC	METRN →	+2.103	+0.279	.005	<.001	3	3
LUNG_NSCLC_LUSC	NCALD →	-0.741	-0.300	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM117B by Neuroepithelial cell differentiation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →