Regulation of vitamin D biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of vitamin D biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPN, STK10, and TNFAIP8L2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vitamin D biosynthetic process activity versus SPN in PDAC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SPN →	+0.705	+0.089	<.001	<.001	3	10
LSCC	STK10 →	+0.414	+0.081	<.001	<.001	3	10
COAD	TNFAIP8L2 →	+0.599	+0.046	<.001	<.001	3	10
GBM	WAS →	+0.665	+0.111	<.001	<.001	3	10
HNSC	WDFY4 →	+0.534	+0.104	<.001	<.001	3	10
GBM	WIPF1 →	+0.354	+0.102	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060556 vs SPN — PDAC

Explore this scatter interactively →