Regulation of vitamin D biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of vitamin D biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3H, EMC2, and CREB3L2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF3H grouped by Regulation of vitamin D biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EIF3H →	+0.706	+1.119	.006	.005	2	7
PANCREAS	EMC2 →	+0.644	+0.725	<.001	.006	3	5
LUNG_NSCLC_LUSC	CREB3L2 →	-1.488	-1.742	.003	<.001	3	4
LUNG_NSCLC_LUSC	FSIP2 →	+1.067	+1.162	.002	.001	3	4
LUNG_NSCLC_LUSC	RUNDC1 →	+0.551	+1.801	.003	<.001	3	4
LARGE_INTESTINE	ENY2 →	+0.759	+1.027	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF3H by Regulation of vitamin D biosynthetic process activity — KIDNEY

Explore this box plot interactively →