Positive regulation of necroptotic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of necroptotic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF133, ZNF629, and RBBP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF133 grouped by Positive regulation of necroptotic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF133 →	-0.565	-0.739	.002	.004	3	4
OESOPHAGUS	ZNF629 →	-0.910	-0.309	.006	.001	3	4
CNS	RBBP9 →	-0.527	-0.539	.001	.005	3	3
LUNG_NSCLC_LUSC	CNOT6L →	-0.907	-0.348	<.001	.003	3	3
LUNG_NSCLC_LUSC	NAP1L4 →	-0.618	-0.352	.004	.002	3	3
LUNG_NSCLC_LUSC	GOLGA3 →	-0.629	-0.361	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF133 by Positive regulation of necroptotic process activity — CNS

Explore this box plot interactively →