Respiratory system development

Across TCGA patient cohorts, RNA activity of the Respiratory system development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANTXR1, TRPC1, and RUNX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory system development activity versus ANTXR1 in CCRCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANTXR1 →	+1.271	+0.166	<.001	<.001	3	5
BRCA	TRPC1 →	+1.148	+0.215	.001	.006	3	5
PDAC	RUNX2 →	+1.224	+0.226	.002	.005	3	4
OV	MED6 →	+0.575	+0.230	<.001	<.001	3	4
BRCA	HTRA1 →	+2.337	+0.234	<.001	.003	3	4
OV	MTMR9LP →	+0.692	+0.157	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060541 vs ANTXR1 — CCRCC

Explore this scatter interactively →