Respiratory system development

Across TCGA cell cohorts, RNA activity of the Respiratory system development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRM2, GLOD4, and RPS28, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRM2 grouped by Respiratory system development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRM2 →	-0.489	-0.628	.002	.004	3	4
LARGE_INTESTINE	GLOD4 →	+0.470	+0.564	.002	.002	3	4
KIDNEY	RPS28 →	-0.878	-1.236	<.001	<.001	3	4
BLOOD_Leukemia	FAU →	-0.400	-0.889	.001	.001	3	4
SOFT_TISSUE	RASSF8 →	-2.900	-1.488	.004	<.001	3	4
SOFT_TISSUE	DENND5B →	-1.684	-1.511	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRM2 by Respiratory system development activity — PANCREAS

Explore this box plot interactively →