Respiratory system development

Across TCGA cell cohorts, RNA activity of the Respiratory system development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBNL, TMSB10, and FAM111A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory system development activity versus DBNL in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DBNL →	+1.328	+0.457	<.001	<.001	3	5
LIVER	TMSB10 →	+1.021	+0.416	.003	.002	3	5
SOFT_TISSUE	FAM111A →	+1.932	+0.465	.009	.002	3	4
SOFT_TISSUE	TUBA1C →	+1.214	+0.373	.001	.003	2	5
SOFT_TISSUE	ECE1 →	+2.327	+0.549	.005	<.001	3	4
SKIN	HEBP2 →	+0.999	+0.227	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060541 vs DBNL — LIVER

Explore this scatter interactively →