Diaphragm development

Across TCGA patient cohorts, RNA activity of the Diaphragm development pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are YJU2_S179, EFEMP1, and FSTL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diaphragm development activity versus YJU2_S179 in UCEC (Pearson r = -0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YJU2_S179 →	-0.756	-0.105	<.001	<.001	3	4
BRCA	EFEMP1 →	+0.413	+0.027	<.001	.002	3	4
BRCA	FSTL1 →	+0.573	+0.045	<.001	<.001	3	4
PDAC	IGFBP3 →	+0.609	+0.046	<.001	.001	3	4
BRCA	LOX →	+0.586	+0.044	<.001	<.001	3	4
BRCA	MRPL27 →	-0.266	-0.032	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060539 vs YJU2_S179 — UCEC

Explore this scatter interactively →