Diaphragm development

Across TCGA patient cohorts, RNA activity of the Diaphragm development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, SCN2B, and SYNDIG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diaphragm development activity versus BASP1 in LSCC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BASP1 →	+1.147	+1.325	<.001	<.001	3	7
BRCA	SCN2B →	+0.394	+0.716	<.001	.002	3	5
HNSC	SYNDIG1 →	+0.842	+0.429	.002	.003	3	4
COAD	GALNT15 →	+0.945	+0.180	<.001	<.001	3	4
COAD	CERCAM →	+0.941	+0.197	<.001	<.001	3	4
HNSC	FIBIN →	+0.883	+0.460	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060539 vs BASP1 — LSCC

Explore this scatter interactively →