Diaphragm development

Across TCGA cell cohorts, RNA activity of the Diaphragm development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB21, RASSF3, and PNPLA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB21 grouped by Diaphragm development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ZBTB21 →	+0.572	+0.916	.008	.002	3	4
LARGE_INTESTINE	RASSF3 →	+0.839	+0.979	.003	.001	3	3
OVARY	PNPLA2 →	-1.008	-1.422	<.001	<.001	3	3
OVARY	CDH3 →	-2.570	-1.204	.006	.006	3	3
LUNG_NSCLC_LUSC	VAMP4 →	+0.893	+1.350	<.001	.001	3	3
BLOOD_Myeloma	SDCBP →	+1.546	+1.853	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB21 by Diaphragm development activity — PANCREAS

Explore this box plot interactively →