Diaphragm development

Across TCGA cell cohorts, RNA activity of the Diaphragm development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLRC1, GZMM, and SLC17A4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLRC1 grouped by Diaphragm development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KLRC1 →	+0.320	+0.214	.003	.002	3	3
BREAST	GZMM →	-0.233	-0.474	.002	.001	3	3
SOFT_TISSUE	SLC17A4 →	-0.218	-1.299	<.001	.001	3	3
SOFT_TISSUE	NPY1R →	-0.145	-1.062	.002	.003	3	3
SOFT_TISSUE	ZNF565 →	+0.342	+1.212	.007	.004	3	3
BLOOD_Leukemia	DDX25 →	+0.173	+0.468	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLRC1 by Diaphragm development activity — BREAST

Explore this box plot interactively →