Skeletal muscle organ development

Across TCGA patient cohorts, RNA activity of the Skeletal muscle organ development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3G, NID1, and RSU1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle organ development activity versus EIF3G in OV (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EIF3G →	-0.249	-0.029	.005	.002	3	7
HNSC	NID1 →	+0.522	+0.054	<.001	<.001	3	7
BRCA	RSU1 →	+0.341	+0.023	.002	<.001	3	6
UCEC	SORBS3 →	+0.514	+0.044	<.001	<.001	3	6
BRCA	SSC5D →	+0.686	+0.017	<.001	<.001	3	6
HNSC	SYNPO →	+0.642	+0.066	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060538 vs EIF3G — OV

Explore this scatter interactively →