Skeletal muscle organ development

Across TCGA cell cohorts, RNA activity of the Skeletal muscle organ development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHD2, EPB41, and GPR176, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle organ development activity versus EHD2 in LIVER (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EHD2 →	+3.778	+0.386	<.001	.001	3	9
BLOOD_Leukemia	EPB41 →	-1.121	-0.294	.001	.001	3	8
LIVER	GPR176 →	+2.900	+0.426	.002	.009	3	8
LIVER	TPM1 →	+2.474	+0.374	.001	.002	3	7
SKIN	CCN1 →	+3.127	+0.310	<.001	<.001	3	7
SKIN	TNIP1 →	+1.123	+0.220	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060538 vs EHD2 — LIVER

Explore this scatter interactively →