Cartilage morphogenesis

pathway activity — cross-omics
GO:0060536Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cartilage morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STC1, BAG6_S964, and AKR1B10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADSTC1 →+1.137+0.321<.001<.00133
BRCABAG6_S964 →-0.847-0.256<.001<.00133
LUADAKR1B10 →+1.918+0.202<.001<.00133
GBMGNPTG →+0.771+0.861<.001<.00133
BRCAABI3_T134 →+1.008+0.326<.001<.00133
HNSCSORBS1_S665 →-0.531-0.166<.001.00232
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration