Prostatic bud formation

pathway activity — cross-omics
GO:0060513Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Prostatic bud formation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GZMA, TBC1D1, and WNT5A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCGZMA →-0.640-0.107<.001<.00136
HNSCTBC1D1 →-0.400-0.154<.001<.00136
PDACWNT5A →+0.728+0.096.003<.00136
HNSCRASAL3_S988 →-0.653-0.121<.001<.00136
HNSCZAP70 →-0.615-0.147<.001<.00135
BRCACD38 →-0.690-0.070.002.00726
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration