Prostatic bud formation

pathway activity — cross-omics
GO:0060513Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Prostatic bud formation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX1, MXRA7, and LAMC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCCBX1 →+0.578+0.692.006.00334
LSCCMXRA7 →+0.464+0.852.005.00334
PDACLAMC1 →+0.541+1.149<.001<.00133
PDACSLC39A6 →+0.382+0.866.002<.00133
LSCCTPST1 →+0.494+0.904.003.00324
PDACCSRP2 →+0.480+0.796<.001.00933
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration