Prostate gland morphogenesis

Across TCGA patient cohorts, RNA activity of the Prostate gland morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAP1, SEPTIN2, and THBS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostate gland morphogenesis activity versus TAP1 in PDAC (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TAP1 →	-0.444	-0.052	<.001	<.001	3	7
GBM	SEPTIN2 →	+0.222	+0.069	<.001	<.001	3	7
CCRCC	THBS3 →	+0.550	+0.061	.002	.001	3	6
CCRCC	PTN →	+0.985	+0.083	.005	.006	3	6
BRCA	LMCD1 →	+0.649	+0.074	<.001	<.001	3	6
CCRCC	SEC24A →	-0.265	-0.067	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060512 vs TAP1 — PDAC

Explore this scatter interactively →