Prostate gland morphogenesis

Across TCGA patient cohorts, RNA activity of the Prostate gland morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NFATC4, FAM207A, and MAP1A_S1791, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostate gland morphogenesis activity versus NFATC4 in GBM (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NFATC4 →	+0.324	+0.838	<.001	<.001	3	4
BRCA	FAM207A →	-0.463	-0.811	<.001	<.001	3	3
LSCC	MAP1A_S1791 →	+0.594	+0.951	<.001	<.001	3	3
UCEC	OXSR1_S339 →	-0.356	-0.800	.006	<.001	3	3
BRCA	VCL_S346 →	+0.568	+0.691	<.001	<.001	3	3
OV	COMP →	+0.880	+0.653	.003	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060512 vs NFATC4 — GBM

Explore this scatter interactively →