Epithelial cell proliferation involved in lung morphogenesis

pathway activity — cross-omics
GO:0060502Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, MFGE8, and NUMBL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCATLN2 →+0.393+0.053.002.00138
BRCAMFGE8 →+0.622+0.061.002<.00137
BRCANUMBL →+0.379+0.059<.001.00137
GBMSEPTIN4 →+0.622+0.094<.001<.00136
PDACSORBS3 →+0.414+0.101<.001<.00136
BRCATNS1 →+0.487+0.071.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration