Epithelial cell proliferation involved in lung morphogenesis

pathway activity — cross-omics
GO:0060502Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C12orf57, FDFT1, and ANKRD37, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECC12orf57 →+0.855+0.167.002.00334
UCECFDFT1 →+0.549+0.231.004<.00134
CCRCCANKRD37 →+0.365+0.204.006.00634
GBMKAT8 →+0.247+0.215<.001<.00134
GBMKHDC4 →+0.290+0.193.002.00734
GBMXPA →+0.491+0.220<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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